Dr. J. Collister

Office:     295g AS/VM, 1988 Fitch Ave, St.Paul Campus
Phone:     612-626-1206
Fax:         612-625-0204
E-mail:   colli066@umn.edu

Education:
     PhD 1999 University of Minnesota
     DVM 1994 University of Illinois

Current teaching responsibilities:
     CVM 6111 Cells & Tissues
     MVB 8201 Mechanisms of Animal Health and Disease I
     MVB 8202 Mechanisms of Animal Health and Disease II

Academic interests:

The research in my lab is primarily focused on better understanding the long-term control of arterial blood pressure. Hypertension is a common pathophysiologic process that is a component of many human and animal disease syndromes. A clear understanding of normal blood pressure regulation will lead to a better understanding of the pathophysiologic mechanisms of hypertension. Primarily, the lab is focused on the link between hormonal systems (such as the renin angiotensin system), central sites of action of these hormones and the regulation of sympathetic nervous system outflow. We have focused our attention on the plasma hormone, angiotensin II, and examined its role in blood pressure regulation at 2 specific brain regions (the area postrema and the subfornical organ) known as circumventricular organs. We use the rat as a model in our experiments and the use of radiotelemetry to continuously measure arterial pressure and heart rate in conscious, freely moving, rats for up to 6 months.

Collister, J. P., B. J. Hornfeldt and J. W. Osborn. Hypotensive response to losartan in normal rats: role of AngII and the area postrema. Hypertension. 27(part 2): 598-606, 1996.

Collister, J. P. and J. W. Osborn. Area postrema lesion attenuates the long-term hypotensive effects of losartan in salt-replete rats. Am. J. Physiol. 274: R357-R366, 1998.

Xu, L., J. P. Collister, J. W. Osborn and V. L. Brooks. Effects of losartan on sympathetic activity and heart rate in sodium deprived rats: role of the area postrema. Am. J. Physiol. 275: R46-R55, 1998.

Collister, J. P. and J. W. Osborn. The area postrema does not modulate the long-term salt-sensitivity of arterial pressure. Am. J. Physiol. 275: R1209-R1217, 1998.

Carlson, S., J. P. Collister and J. W. Osborn. The area postrema modulates hypothalamic Fos responses to intragastric hypertonic saline in conscious rats. Am. J. Physiol. 275: R1921-R1927, 1998.

Osborn, J. W., J. P. Collister, and S. H. Carlson. Angiotensin and osmoreceptor in puts to the area postrema: Role in long-term control of fluid homeostasis and arterial pressure. Clin. Exp. Pharm. Physiol. 27: 443-449, 2000.

Collister, J. P. and J. W. Osborn. The chronic infusion of hexamethonium and phenylephrine to effectively clamp the sympathetic nervous system. J. Pharm. Toxicol. Methods. 42: 135-147, 2001.

Collister, J. P., S. L. Soucheray and J. W. Osborn. The chronic hypotensive response to losartan in normotensive, salt-replete rats is not dependent on the actions of angiotensin II at AT2 receptors. J. Cardiovasc. Pharm. 39: 107-116, 2002.

Collister, J.P. and M. Hendel. The role of the subfornical organ in mediating the chronic hypotensive effects of losartan in normal rats. Hypertension. 41 (3): 576-582, 2003.

Ariza-Nieto, P., J. P. Collister, S. L. Soucheray and J. W. Osborn. Acute and chronic salt-sensitivity of arterial pressure (AP) in rats with fixed low, normal and high plasma angiotensin II (AngII). Am. J. Physiol. (Accepted, In Press), 2003.

Collister, J.P. and M.D. Hendel. The role of Ang(1-7) in mediating the chronic hypotensive effects of losartan in normal rats. JRAAS. (Accepted, In Press), 2003.

Collister, J.P. and M.D. Hendel. Subfornical organ lesion attenuates chronic hypotensive effects of losartan in salt-replete rats. JRAAS. (Submitted), 2003.

Collister, J. P. and J. W. Osborn. The chronic hypotensive effects of losartan and the role of a responsive sympathetic nervous system. J. Cardiovasc. Pharm. (Submitted), 2003.